Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor
Xiaobo Zhong, Le Zhang, Gilles P. van Wezel, Erik Vijgenboom, Dennis Claessen
Abstract
Lytic polysaccharide monooxygenases are used in industry for the efficient degradation of recalcitrant polysaccharide substrates. Only recently, we have begun to appreciate some of their important biological roles. In this article, we provide evidence that these enzymes are involved in remodeling peptidoglycan, which is a conserved component of the bacterial cell wall. Given that lytic polysaccharide monooxygenases are commonly found in microbes, this newly identified biological role in cell wall remodeling may be widespread.
Topics & Concepts
PeptidoglycanLytic cycleCell wallGlycanStreptomyces coelicolorPolysaccharideBacterial cell structureBiologyBiochemistryMicrobiologyMonooxygenaseLysinStreptomycesBacteriaEnzymeCell biologyChemistryEscherichia coliGeneBacteriophageVirologyVirusCytochrome P450GlycoproteinGeneticsEnzyme Production and CharacterizationGenomics and Phylogenetic StudiesLegume Nitrogen Fixing Symbiosis