Cu/base co-catalyzed [3+3] cycloaddition for the synthesis of highly functionalized 4-fluoropyridines
Jinhuan Dong, Wanzhong Feng, Lei Wang, Mei Li, Zhe Chen, Xianxiu Xu
Abstract
An efficient, straightforward and general method for the de novo synthesis of highly functionalized 4-fluoropyridines was developed via a cooperative copper- and base-catalyzed [3+3] cycloaddition of active methylene isocyanides with difluorocyclopropenes.
Topics & Concepts
CycloadditionCatalysisNucleophileCombinatorial chemistryChemistryBase (topology)MethyleneCopperOrganic chemistryMathematicsMathematical analysisFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms