Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci
Tina H. Dao, Ramzi Alsallaq, Joshua B. Parsons, Jose Ferrolino, Randall T. Hayden, Jeffrey E. Rubnitz, Iftekhar Rafiqullah, D. Ashley Robinson, Elisa Margolis, Jason W. Rosch, Joshua Wolf
Abstract
0.001). This effect persisted after controlling for identified confounders. These data indicate that vancomycin heteroresistance is common in CoNS isolates from CLABSIs in pediatric patients with leukemia and is associated with poor clinical outcomes. Validation of these findings in an independent cohort and evaluation of alternative antibiotic therapy in patients with heteroresistant infections have the potential to improve care for serious CoNS infections.
Topics & Concepts
VancomycinMedicineBacteremiaAntibioticsInternal medicinePopulationCoagulaseCohortIntensive care medicineMicrobiologyStaphylococcus aureusStaphylococcusBiologyBacteriaGeneticsEnvironmental healthAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingNeonatal and Maternal Infections