Regio- and enantioselective ring-opening reaction of vinylcyclopropanes with indoles under cooperative catalysis
Xiao Wan, Meng Sun, Jing‐Yi Wang, Yu Lei, Qiong Wu, Yu‐Chen Zhang, Feng Shi
Abstract
The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products with branched selectivity in moderate yields and good enantioselectivities.
Topics & Concepts
ChemistryBimetallic stripIndole testEnantioselective synthesisCatalysisIridiumSelectivityRing (chemistry)Combinatorial chemistryCopperOrganic chemistryMedicinal chemistryCyclopropane Reaction MechanismsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis