Cancer phototherapy by CO releasing terpyridine-based Re(<scp>i</scp>) tricarbonyl complexes <i>via</i> ROS generation and NADH oxidation
Rajesh Kushwaha, Aarti Upadhyay, Sukanta Saha, Ashish Kumar Yadav, Arpan Bera, Arnab Dutta, Samya Banerjee
Abstract
∼ 2 µM) by inducing ROS-mediated cell death in cancer cells selectively (photocytotoxicity Index, PI > 28) upon compromising mitochondrial function in A549 cells. Their diagnostic capabilities were ultimately assessed using clinically relevant 3D multicellular tumor spheroids (MCTs).
Topics & Concepts
TerpyridineChemistryPhotochemistryVisible spectrumCombinatorial chemistryMetalOrganic chemistryMaterials scienceOptoelectronicsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryAdenosine and Purinergic Signaling