Phosphine-catalyzed enantioselective [4 + 1] annulation of oxindoles with allenic ketones for the construction of spirocyclopentene oxindoles
Xiaodong Tang, Huanzhen Ni, Yixin Lü
Abstract
A phosphine-catalyzed enantioselective [4 + 1] annulation between allenic ketones and oxindoles has been developed.
Topics & Concepts
AnnulationEnantioselective synthesisPhosphineChemistryCatalysisOrganic chemistryMedicinal chemistryCombinatorial chemistryStereochemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods