Three-component selective synthesis of phenothiazines and bis-phenothiazines under metal-free conditions
Shanping Chen, Zhuoqin Li, Kai Hu, Wei Feng, Guojiang Mao, Fuhong Xiao, Guo‐Jun Deng
Abstract
An iodine-containing reagent promoted three-component method for the selective synthesis of phenothiazines and bis-phenothiazines has been developed. The present protocol starts from simple and easily available cyclohexanones, elemental sulfur, and inorganic ammonium salts, selectively producing phenothiazines and bis-phenothiazines in satisfactory yields under aerobic conditions. This method has the advantages of simple and readily available starting materials and metal-free conditions, affording a facile and practical approach for the preparation of phenothiazines and bis-phenothiazines.
Topics & Concepts
Component (thermodynamics)ChemistryPhysicsThermodynamicsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Reactivity of HeterocyclesSynthesis and Reactivity of Sulfur-Containing Compounds