Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species
Ufuk Karakus, Dilara Şahin, Peer R. E. Mittl, Petra Mooij, Gerrit Koopman, Onur Boyman
Abstract
cells in freshly isolated human T cells ex vivo and in mice and rhesus macaques in vivo. The crystal structure of the IL-2/UFKA-20 complex demonstrated that UFKA-20 interfered with IL-2 binding to CD122 and, to a lesser extent, also CD25. Together, we translated CD25-biased IL-2 complexes from mice to nonhuman primates and extended our mechanistic understanding of how CD25-biasing anti-human IL-2 antibodies work, which paves the way to clinical trials of CD25-biased IL-2 complexes.
Topics & Concepts
AntibodyReceptorCell biologyImmunologyChemistryBiologyMedicineBiochemistryT-cell and B-cell ImmunologyImmune Cell Function and InteractionCAR-T cell therapy research