Red-light excitation of a Ru( <scp>ii</scp> )–Pt( <scp>ii</scp> ) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy
Pia Siekierski, Eleni Michaltsis, Julia Schleisiek, Nicolás Montesdeoca, Johannes Karges
Abstract
We report the synthesis and biological evaluation of a tetranuclear Ru(II)-Pt(II) complex activated by red light (630 nm). Upon irradiation, the Ru(II) center photo-catalytically generates singlet oxygen while simultaneously releasing Pt(II) moieties, thereby inducing a multimodal therapeutic effect in cancer cells by photodynamic therapy and photoactivated chemotherapy.
Topics & Concepts
Photodynamic therapySinglet oxygenChemistryPhotosensitizerExcitationCancer researchPhototoxicityCancer cellRed lightPhotochemistryCancer therapyChemotherapyCancerSinglet stateReactive oxygen speciesCancer treatmentBiophysicsFluorescenceVisible spectrumCytotoxicityOxygenMetal complexes synthesis and propertiesPorphyrin and Phthalocyanine ChemistryMagnetism in coordination complexes