Intratympanic application of poloxamer 407 hydrogels results in sustained N-acetylcysteine delivery to the inner ear
Julia Clara Gausterer, Nodir Saidov, Navid Ahmadi, Chengjing Zhu, Michael Wirth, Gottfried Reznicek, Christoph Arnoldner, Franz Gabor, Clemens Honeder
Topics & Concepts
AcetylcysteinePerilymphPoloxamerPharmacologyChemistryOtotoxicitySelf-healing hydrogelsPharmacokineticsInner earDrug deliveryAntidoteSystemic administrationPoloxamer 407Cerebrospinal fluidAntioxidantMedicineToxicityAnesthesiaIn vivoCisplatinChemotherapyBiochemistrySurgeryInternal medicineAnatomyBiologyOrganic chemistryPolymerBiotechnologyCopolymerHearing, Cochlea, Tinnitus, GeneticsElectron Spin Resonance StudiesVestibular and auditory disorders