The Project Baseline Health Study: a step towards a broader mission to map human health
Kristine Arges, Themistocles L. Assimes, Vikram S. Bajaj, Suresh Balu, Mustafa R. Bashir, Laura M. Beskow, Rosalia Blanco, Robert M. Califf, Paul Campbell, Larry Carin, Victoria Christian, Scott W. Cousins, Millie Das, Marie Dockery, Pamela S. Douglas, Ashley Dunham, Julie Eckstrand, Dominik Fleischmann, Emily Ford, Elizabeth Fraulo, John French, Sanjiv S. Gambhir, Geoffrey S. Ginsburg, Robert C. Green, François Haddad, Adrian F. Hernandez, John Hernandez, Erich Huang, Glenn J. Jaffe, Daniel A. King, Lynne Koweek, Curtis P. Langlotz, Yaping Joyce Liao, Kenneth W. Mahaffey, Kelly Marcom, William J. Marks, David J. Maron, Reid McCabe, Shannon J. McCall, Rebecca McCue, Jessica L. Mega, David P. Miller, Lawrence H. Muhlbaier, Rajan Munshi, L. Kristin Newby, Ezra Pak-Harvey, Bray Patrick‐Lake, Michael J. Pencina, Eric D. Peterson, Fátima Rodríguez, Scarlet Shore, Svati H. Shah, Steven Shipes, George W. Sledge, Susie Spielman, Ryan Spitler, Terry Schaack, Geeta K. Swamy, Martin J. Willemink, Charlene A. Wong
Abstract
The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical information system that accounts for the highly complex interplay of biological, behavioral, environmental, and social systems. The PBHS is a prospective, multicenter, longitudinal cohort study that aims to enroll thousands of participants with diverse backgrounds who are representative of the entire health spectrum. Enrolled participants will be evaluated serially using clinical, molecular, imaging, sensor, self-reported, behavioral, psychological, environmental, and other health-related measurements. An initial deeply phenotyped cohort will inform the development of a large, expanded virtual cohort. The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis.