A synthetic glycan array containing <i>Cryptococcus neoformans</i> glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes
Lorenzo Guazzelli, C. Crawford, Rebecca Ulc, Anthony Bowen, Orla McCabe, Anne J. Jedlicka, Maggie P. Wear, Arturo Casadevall, Stefan Oscarson
Abstract
A library of <italic>Cryptococcus neoformans</italic> glucuronoxylomannan (GXM) oligosaccharides was synthesized using a thioglycoside building block strategy. The first GXM microarray was printed, allowing mapping of epitopes of antibodies directed towards GXM.
Topics & Concepts
Cryptococcus neoformansGlycanEpitopeMicrobiologyBiologyComputational biologyChemistryAntibodyBiochemistryImmunologyGlycoproteinFungal Infections and StudiesAntifungal resistance and susceptibilityPlant Disease Resistance and Genetics