Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses
Qinqin Sun, Xiaojuan Li, Ersheng Kuang
Abstract
As a new emerging severe coronavirus, the knowledge on the SARS-CoV-2 and COVID-19 remains very limited, whereas many concepts can be learned from the homologous coronaviruses. Macroautophagy/autophagy is finely regulated by SARS-CoV-2 infection and plays important roles in SARS-CoV-2 infection and pathogenesis. This review will explore the subversion and mechanism of the autophagy-related machinery, vacuoles and organelle-specific autophagy during infection of SARS-CoV-2 and coronaviruses to provide meaningful insights into the autophagy-related therapeutic strategies for infectious diseases of SARS-CoV-2 and coronaviruses.
Topics & Concepts
AutophagyBiologyOrganelleCoronavirusVacuoleSubversionCoronaviridaeVirologyMechanism (biology)Cell biologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)CytoplasmInfectious disease (medical specialty)GeneticsDiseaseMedicineLawApoptosisEpistemologyPoliticsPathologyPhilosophyPolitical scienceAutophagy in Disease and TherapyExtracellular vesicles in diseasePhagocytosis and Immune Regulation