Effects of Grape Seed Proanthocyanidin Extract on Obesity
Miao Liu, Peng Yun, Ying Hu, Jiao Yang, Rim Bahadur Khadka, Xiaochun Peng
Abstract
Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors. As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer. Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect. This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.
Topics & Concepts
MedicineObesityHyperlipidemiaDiabetes mellitusMetabolic syndromeDiseaseProanthocyanidinInternal medicineStroke (engine)Type 2 diabetesBioinformaticsEndocrinologyAntioxidantBiochemistryPolyphenolEngineeringBiologyMechanical engineeringChemistryAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity