Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1
Johanna M. Eberhard, Mathieu Angin, Caroline Passaes, María Salgado, Valérie Monceaux, Elena Knops, Guido Kobbe, Björn‐Erik Ole Jensen, Maximilian Christopeit, Nicolaus Kröger, Linos Vandekerckhove, Jon Badiola, Alessandra Bandera, Kavita Raj, Jan van Lunzen, Gero Hütter, Jürgen Kuball, Carolina Martínez‐Laperche, Pascual Balsalobre, Mi Kwon, José L. Díez‐Martín, Monique Nijhuis, Annemarie M. J. Wensing, Javier Martínez‐Picado, Julian Schulze zur Wiesch, Asier Sáez‐Cirión
Abstract
T cells and persisted years after allo-HSCT. In conclusion, immune reconstitution was slow, heterogeneous, and incomplete and coincided with de novo detection of weak HIV-specific T cell responses. The initial short phase of high T cell activation, in which HIV antigens were present, may constitute a window of vulnerability for the reseeding of viral reservoirs, emphasizing the importance of maintaining ART directly after allo-HSCT.