CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1
Jingyu Liao, Zeyu Chen, Ruizhi Chang, Tong Yuan, Ganxun Li, Chang Zhu, Jingyuan Wen, Wei Yi, Zhao Huang, Zeyang Ding, Liang Chu, Junnan Liang, Bixiang Zhang
Abstract
. Mechanistically, CENPA transcriptionally activated and cooperated with YY1 to drive the expression of cyclin D1 (CCND1) and neuropilin 2 (NRP2). Moreover, we identified that CENPA can be lactylated at lysine 124 (K124). The lactylation of CENPA at K124 promotes CENPA activation, leading to enhanced expression of its target genes. In summary, CENPA function as a transcriptional regulator to promote HCC via cooperating with YY1. Targeting the CENPA-YY1-CCND1/NRP2 axis may provide candidate therapeutic targets for HCC.
Topics & Concepts
YY1Gene knockdownCyclin D1RegulatorMitosisCancer researchBiologyTranscriptional regulationCyclin BCyclin B1Cell biologyChromosome segregationCell growthTranscription factorCell cycleGeneGene expressionChromosomeGeneticsCyclin-dependent kinase 1PromoterMicrotubule and mitosis dynamicsEpigenetics and DNA MethylationUbiquitin and proteasome pathways