3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease
Selene Lomoio, Ravi S. Pandey, Nicolas Rouleau, Beatrice Menicacci, WonHee Kim, William Cantley, Philip G. Haydon, David A. Bennett, Tracy L. Young‐Pearse, Gregory W. Carter, David L. Kaplan, Giuseppina Tesco
Topics & Concepts
PhenotypeTranscriptomeInduced pluripotent stem cellNeuroscienceExtracellularBiologyAlzheimer's diseaseNeurodegenerationExtracellular matrixCell biologyDiseaseGenePathologyGeneticsGene expressionMedicineEmbryonic stem cellAlzheimer's disease research and treatmentsNerve injury and regenerationSilk-based biomaterials and applications