A novel platinum(IV) prodrug, gramine-Pt(IV) enhances chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis
Bowen Ding, Xiaomeng Liu, Zhe Li, Xinru Xie, Jiaqi Li, Jiaqian Wang, Shouyi Li, Pengyu Wang, Yongjie Xie, Xiaoqing Ma, Hongwei Wang, Cheng‐Zhi Xie, Xin Qiao, Yumin Wang, Jing‐Yuan Xu, Yukuan Feng, Jihui Hao
Topics & Concepts
ProdrugChemoimmunotherapyStingPharmacologyPlatinumMedicineChemistryInternal medicineImmunotherapyPhysicsBiochemistryCancerThermodynamicsCatalysisinterferon and immune responsesCancer Mechanisms and TherapyAdenosine and Purinergic Signaling