Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β
Ayaka Nakai, Tomoyuki Fujiyama, Nanae Nagata, Mitsuaki Kashiwagi, Aya Ikkyu, Marina Takagi, Chika Tatsuzawa, Kaeko Tanaka, Miyo Kakizaki, Mika Kanuka, Taizo Kawano, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa, Yu Hayashi
Abstract
Abstract Humans families carrying mutations in transcription factor AP-2β (TFAP2B) self-reported sleep abnormalities. Notably, AP-2 transcription factors play essential roles in invertebrate sleep, implicating a conserved role across the animal phyla. Nakai et al. generated two .....
Topics & Concepts
Transcription factorBiologyGeneticsTranscription (linguistics)Sleep (system call)PhylumGeneLinguisticsOperating systemPhilosophyComputer scienceCircadian rhythm and melatoninGenetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation