Facile synthesis of a glutathione-depleting Cu(<scp>ii</scp>)-half-salamo-based coordination polymer for enhanced chemodynamic therapy
Wenting Guo, Tongxi Ji, Yun‐Hu Deng, Jia Liu, Yantong Gou, Wen‐Kui Dong
Abstract
to generate toxic ˙OH through a Fenton-like reaction to enhance their anticancer efficacy. Our study provides useful insights into designing smarter metal-based anticancer agents to improve the CDT efficiency in cancer therapy.
Topics & Concepts
GlutathioneChemistryInternalizationIntracellularCoordination polymerCancer cellAlkoxy groupCombinatorial chemistryCatalysisSelectivityRadicalPolymerBiophysicsBiochemistryCancerOrganic chemistryReceptorEnzymeBiologyAlkylGeneticsMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers