Structures of the <i>Mononegavirales</i> Polymerases
Bo Liang
Abstract
Mononegavirales , known as nonsegmented negative-sense (NNS) RNA viruses, are a class of pathogenic and sometimes deadly viruses that include rabies virus (RABV), human respiratory syncytial virus (HRSV), and Ebola virus (EBOV). Unfortunately, no effective vaccines and antiviral therapeutics against many Mononegavirales are currently available. Viral polymerases have been attractive and major antiviral therapeutic targets. Therefore, Mononegavirales polymerases have been extensively investigated for their structures and functions.
Topics & Concepts
MononegaviralesBiologyVirologyPolymeraseParamyxoviridaeEbola virusRhabdoviridaeVirusRabies virusPneumovirinaeRNA virusLyssavirusRNAViral diseaseGeneticsGeneBacteriophages and microbial interactionsViral Infections and Outbreaks ResearchVirology and Viral Diseases