Structural insights into probe-dependent positive allosterism of the GLP-1 receptor
Ana B. Bueno, Bingfa Sun, Francis S. Willard, Dan Feng, Joseph D. Ho, David B. Wainscott, Aaron D. Showalter, Michal Vieth, Qi Chen, Cynthia Stutsman, Betty Chau, James Ficorilli, Francisco J. Agejas, Graham R. Cumming, Alma Jiménez, I. Rojo, Tong Sun Kobilka, Brian K. Kobilka, Kyle W. Sloop
Topics & Concepts
Allosteric regulationG protein-coupled receptorChemistryHeterotrimeric G proteinLigand (biochemistry)ReceptorAllosteric modulatorPeptideBiophysicsDrug discoveryBiochemistryStereochemistryG proteinBiologyReceptor Mechanisms and SignalingDiabetes Treatment and ManagementPancreatic function and diabetes