Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy
Kerstin Pohl, Xue A. Grimm, Silvia M. Caceres, Katie R. Poch, N. Rysavy, Milene T. Saavedra, Jerry A. Nick, Kenneth C. Malcolm
Abstract
Mycobacterium abscessus , a rapidly growing nontuberculous mycobacterium, is increasingly prevalent in chronic lung disease, including cystic fibrosis, and infections are characterized by neutrophil-dominated environments. However, mechanisms of immune control are poorly understood. Azithromycin, a macrolide antibiotic with immunomodulatory effects, is used to treat M. abscessus infections. Recently, inhibition of macrophage bactericidal autophagy was described for azithromycin, which could be detrimental to the host.
Topics & Concepts
Mycobacterium abscessusAzithromycinNontuberculous mycobacteriaCystic fibrosisBiologyMicrobiologyImmunologyImmune systemAntibioticsMycobacteriumLung diseaseAutophagyMacrophageLungBacteriaMedicineIn vitroApoptosisGeneticsInternal medicineBiochemistryMycobacterium research and diagnosisTuberculosis Research and EpidemiologyQuinazolinone synthesis and applications