Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Satish S. Phalake, Sandeep B. Somvanshi, Syed A. M. Tofail, Nanasaheb D. Thorat, Vishwajeet M. Khot
Abstract
assessment of MCF-7 breast cancer cell lines in 2D and 3D cell cultures demonstrated anticancer activity. In the 2D and 3D cancer models, the MIONP-mediated MCT reduced cancer cell viability to about 71.48% and 92.2%, respectively. On the other hand, MIONP-mediated MCT under an AC magnetic field diminished spheroids' viability to 83.76 ± 2%, being the most promising therapeutic modality against breast cancer.
Topics & Concepts
ManganeseNanoparticleMagnetoDual (grammatical number)Breast cancerManganese oxideMaterials scienceCancerIron oxide nanoparticlesCancer researchNanotechnologyChemistryMedicineInternal medicineMetallurgyOrganic chemistryCombustionLiteratureArtNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesGraphene and Nanomaterials Applications