Chinese chestnut shell polyphenol extract regulates the JAK2/STAT3 pathway to alleviate high-fat diet-induced, leptin-resistant obesity in mice
Suwen Liu, Wenhong Jiang, Chang Liu, Shuo Guo, Hao Wang, Xuedong Chang
Abstract
Chinese chestnut shell polyphenol (CSP) reduce inflammation and increase antioxidant capacity, and activating the LEPR-JAK2/STAT3-PTP1B-SOCS-3 signal transduction pathway to alleviate high-fat diet–induced, leptin-resistant obesity in mice.
Topics & Concepts
LeptinPolyphenolObesityFat accumulationSTAT3ChemistryInternal medicineEndocrinologyPharmacologyBiologyMedicineSignal transductionBiochemistryAntioxidantAdipokines, Inflammation, and Metabolic DiseasesGinseng Biological Effects and ApplicationsRegulation of Appetite and Obesity