Expression Patterns of Plasmodium falciparum Clonally Variant Genes at the Onset of a Blood Infection in Malaria-Naive Humans
Anastasia K. Pickford, Lucas Michel-Todó, Florian Dupuy, Alfredo Mayor, Pedro L. Alonso, Catherine Lavazec, Alfred Cortés
Abstract
The ability of malaria parasites to adapt to changes in the human blood environment, where they produce long-term infection associated with clinical symptoms, is fundamental for their survival. CVGs, regulated at the epigenetic level, play a major role in this adaptive process, as changes in the expression of these genes result in alterations in the antigenic and functional properties of the parasites.
Topics & Concepts
BiologyEpigeneticsPlasmodium falciparumGeneTranscriptomeMalariaGene expressionGeneticsGene expression profilingImmunologyMalaria Research and ControlParasites and Host InteractionsMosquito-borne diseases and control