Calprotectin (S100A8/A9) Is an Innate Immune Effector in Experimental Periodontitis
Karen F. Johnstone, Yuping Wei, Peter D. Bittner‐Eddy, Gerrit Vreeman, Ian A. Stone, Jonathan B. Clayton, Cavan Reilly, Travis B. Walbon, Elisa N. Wright, Suzie Hoops, William S. Boyle, Massimo Costalonga, Mark C. Herzberg
Abstract
mice in their immune cell infiltrates and alveolar bone loss. Calprotectin, therefore, suppresses emergence of a dysbiotic, proinflammatory oral microbial community, which reduces innate immune effector activity, including early recruitment of innate immune cells, mitigating subsequent alveolar bone loss and protecting against experimental periodontitis.
Topics & Concepts
Innate immune systemPeriodontitisCalprotectinBiologyImmunologyImmune systemS100A9InflammationAntimicrobial peptidesMicrobiologyMedicineAntimicrobialPathologyInternal medicineInflammatory bowel diseaseDiseaseS100 Proteins and AnnexinsImmune Response and InflammationOral microbiology and periodontitis research