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Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance

Yi Gong, Fengxu Wu, Mingshu Wang, Hong-Chuang Xu, Linsheng Zhuo, Guang‐Fu Yang, Wei Huang

2022European Journal of Medicinal Chemistry16 citationsDOIOpen Access PDF

Topics & Concepts

Trk receptorChemistryTropomyosin receptor kinase APyrimidineStereochemistryIC50KinasePharmacologyReceptorIn vitroBiochemistryMedicineNeurotrophinMelanoma and MAPK PathwaysQuinazolinone synthesis and applicationsProtein Degradation and Inhibitors
Discovery of 3-pyrazolyl-substituted pyrazolo[1,5-a]pyrimidine derivatives as potent TRK inhibitors to overcome clinically acquired resistance | Litcius