Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core
Qiuyue Zhang, Xuexuan Wu, Jianrui Zhou, Lixiao Zhang, Xiaoli Xu, Lianshan Zhang, Qidong You, Lei Wang
Topics & Concepts
CDC37ChemistryHsp90Small moleculeKinaseBiochemistryChaperone (clinical)Protein–protein interactionProtein kinase AHeat shock proteinPathologyExtracellular signal-regulated kinasesGeneMedicineHeat shock proteins researchToxin Mechanisms and ImmunotoxinsComputational Drug Discovery Methods