Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
Brigitt Raux, Karly Buchan, James M. Bennett, Thomas Christott, Matthew Dowling, Gillian Farnie, Oleg Fedorov, Vicki Gamble, C. Gileadi, Charline Giroud, K. Huber, Magdalena Korczynska, Chris Limberakis, Arjun Narayanan, Dafydd R. Owen, L. Diaz Saez, Ingrid A. Stock, Allyn T. Londregan
Topics & Concepts
ChemistrySmall moleculeDrug discoveryMoleculeSelectivityCombinatorial chemistryNanotechnologyBiochemistryOrganic chemistryMaterials scienceCatalysisProtein Degradation and InhibitorsEpigenetics and DNA MethylationCancer-related gene regulation