Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization.
Xiaodong Xun, Changkun Zhang, Siqi Wang, Shihua Hu, Xiang Xiao, Qian Cheng, Zhao Li, Yang Wang, Jiye Zhu
Abstract
OBJECTIVE: T cells through regulating TAMs in TIME, thus enhance the T cell-based cytotoxicity and improve the prognosis of HCC patients.
Topics & Concepts
Cytotoxic T cellCancer researchGranzyme BImmune systemCD8T cellTumor microenvironmentImmunotherapyMedicineMacrophage polarizationFlow cytometryGranzymeImmunologyBiologyMacrophagePerforinIn vitroBiochemistryCancer Immunotherapy and BiomarkersCancer, Stress, Anesthesia, and Immune ResponseInflammatory mediators and NSAID effects