Dual-function AzuCR RNA modulates carbon metabolism
Medha Raina, Jordan J. Aoyama, Shantanu Bhatt, Brian J. Paul, Aixia Zhang, Taylor B. Updegrove, Juan Miranda‐Ríos, Gisela Storz
Abstract
SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.
Topics & Concepts
RNABiochemistryBase pairNucleotideBiologyFunction (biology)Amino acidNucleic acidNon-coding RNACell biologyGeneChemistryRNA modifications and cancerRNA and protein synthesis mechanismsRNA Research and Splicing