Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair
Chushan Zheng, Zehong Yang, Shihao Chen, Fang Zhang, Zilong Rao, Cailing Zhao, Daping Quan, Ying Bai, Jun Shen
Abstract
NGCs composed of aligned PLLA nanofibers decorated with 0.25% pDNM gel provided both topological and biochemical guidance for directing and promoting axonal extension, nerve fiber myelination, and functional recovery. Moreover, T2-mapping and DTI metrics were found to be useful non-invasive monitoring techniques for PNI treatment.
Topics & Concepts
DecellularizationSciatic nerveRegeneration (biology)Nerve guidance conduitScaffoldBiomedical engineeringPeripheral nerve injuryMaterials scienceTissue engineeringNerve injuryNanofiberIn vivoAnatomyMedicineSurgeryNanotechnologyBiotechnologyCell biologyBiologyTissue Engineering and Regenerative MedicineNerve injury and regenerationElectrospun Nanofibers in Biomedical Applications