Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis
Zhike Zhou, Yifan Liang, Xiaoqian Zhang, Junjie Xu, Jueying Lin, Rongwei Zhang, Kexin Kang, Chang Liu, Chuansheng Zhao, Mei Zhao
Abstract
Objective: To assess the association between low-density lipoprotein cholesterol (LDL-c) and risk of Alzheimer's disease (AD). Methods: Embase, Pubmed and Web of Science were searched until June 2019. Standard mean difference (SMD) with 95% confidence intervals (CI) was estimated using random-effects models. Results: Our meta-analysis of twenty-six studies revealed higher levels of LDL-c in AD than that of non-dementia controls (SMD=0.35, 95%CI 0.12~0.58, p121 mg/dl) may be a potential risk factor for AD. This association is strong in patients aged 60-70 years, but vanishes with advancing age.
Topics & Concepts
MedicineInternal medicineConfidence intervalMeta-analysisConfoundingDementiaStrictly standardized mean differenceBody mass indexDiabetes mellitusGastroenterologySubgroup analysisDiseaseEndocrinologyAlzheimer's disease research and treatmentsLipoproteins and Cardiovascular HealthDementia and Cognitive Impairment Research