microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis
Zhen Qi, Ruhui Liu, Hai-Ning Ju, Mengxi Huang, Zhe Li, Wei Li, Yongyi Wang
Abstract
. The findings reveal a novel function of miR-130b-3p in attenuating ferroptosis in cardiomyocytes, providing a new therapeutic target for ameliorating septic cardiomyopathy injury.
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayAMPKCell biologyCancer researchSignal transductionChemistryApoptosisBiologyKinaseProtein kinase ABiochemistryMicroRNA in disease regulationRNA modifications and cancerCircular RNAs in diseases