Precise control of the site selectivity in ruthenium-catalyzed C–H bond amidations using cyclic amides as powerful directing groups
Yu‐Chao Yuan, Qiu-Li Lu, Xiaotong Zhu, Sergio Posada‐Pérez, Miquel Solà, Albert Poater, Thierry Roisnel, Rafael Gramage‐Doria
Abstract
A ruthenium-catalyzed C–H amidation using cyclic amides as directing groups features broad functional group tolerance. Mechanistic studies supported by DFT calculations highlight the relevance of six-membered ruthenacycles in the catalytic cycle.
Topics & Concepts
RutheniumCatalysisSelectivityCyclic aminesChemistryCatalytic cycleFunctional groupCombinatorial chemistryStereochemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions