Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates
Rebecca A. Clewell, Jeremy A. Leonard, Chantel I. Nicolas, Jerry L. Campbell, Miyoung Yoon, Alina Efremenko, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell, Katherine A. Phillips, Yu‐Mei Tan
Topics & Concepts
Physiologically based pharmacokinetic modellingPhthalateAdverse Outcome PathwayEcotoxicityRisk assessmentMetaboliteExposure assessmentIn silicoPharmacologyEnvironmental chemistryChemistryToxicologyToxicityComputational biologyPharmacokineticsComputer scienceBiologyMedicineEnvironmental healthBiochemistryGeneOrganic chemistryComputer securityEffects and risks of endocrine disrupting chemicalsAnimal testing and alternativesCarcinogens and Genotoxicity Assessment