Litcius/Paper detail

Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity

Zixia Huang, Conor Whelan, Dina K. N. Dechmann, Emma C. Teeling

2020Aging28 citationsDOIOpen Access PDF

Abstract

have naturally evolved a diminished anti-longevity transcriptomic profile. Together with observations from other long-lived species, our results suggest that heightened DNA repair and autophagy activity may represent a universal mechanism to achieve longevity in long-lived mammals.

Topics & Concepts

LongevityBiologyTranscriptomeGeneEvolutionary biologyGenomePhenotypeGeneticsGene expressionEpigenetics and DNA MethylationBat Biology and Ecology StudiesGenetics, Aging, and Longevity in Model Organisms