Hydrosulfonylation of Alkenes with Sulfonyl Imines via Ir/Cu Dual Photoredox Catalysis
Xian Du, Jing-Song Zhen, Xiaohong Xu, Yuan Han, Yihui Li, Yeqin Zheng, Can Xue, Yong Luo
Abstract
Sulfonamides exhibit the advantages of wide prevalence, excellent prefunctionalization capability, and broad functional group compatibility. We report here utilizing sulfonyl imines as sulfonyl radical precursors for hydrosulfonylation of activated alkenes via visible-light irradiation. By preinstallation of functional groups into the sulfonamides and subsequent hydrosulfonylation, a variety of complex sulfones were synthesized with good efficiency under Ir/Cu dual photoredox catalysis. Additionally, this protocol expands the research in late-stage N-S bond modification in sulfonamides.
Topics & Concepts
ChemistrySulfonylPhotoredox catalysisCatalysisCombinatorial chemistryDual (grammatical number)Organic chemistryPhotocatalysisLiteratureAlkylArtSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions