An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses
Eva Gutiérrez, Mitchell Bigelow, Colin LaCroix, Jeremy Beech, Patrick Kirby, Lynn Markowitz, Michael Shifrin, Michael Naill, Alexandra Braun, Steve O'Neil, Jean-Marie Cuillerot, Ann Cheung, Asya V. Grinberg, Nicolai Wagtmann
Topics & Concepts
In vivoTherapeutic indexBlockadePharmacologyPotencyImmunotherapyPharmacodynamicsIn vitroTherapeutic windowImmune systemToxicityDrugTherapeutic effectInterferonCancer researchMedicineImmunologyBiologyReceptorPharmacokineticsInternal medicineBiotechnologyBiochemistryToxin Mechanisms and ImmunotoxinsVirus-based gene therapy researchMonoclonal and Polyclonal Antibodies Research