Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines
Shi‐Chao Wang, Lin Liu, Mei Duan, Weijia Xie, Jia‐Bin Han, Yuhang Xue, You Wang, Xiaotai Wang, Shaolin Zhu
Abstract
-containing compounds, which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso- and remote hydroamination technique that utilizes organic azides as deprotectable primary amine sources. This strategy offers a highly flexible platform for the efficient construction of α-chiral branched primary amines, as well as linear primary amines.
Topics & Concepts
ChemistryHydroaminationEnantioselective synthesisNickelCatalysisPrimary (astronomy)Combinatorial chemistryOrganic synthesisOrganic chemistryPhysicsAstronomySynthesis and Catalytic ReactionsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods