Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study
Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El‐Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim
Topics & Concepts
HeLaDihydrofolate reductaseChemistryApoptosisCell cultureMCF-7CytotoxicityCancer cellCancerCell growthBiochemistryCell cycleGrowth inhibitionCancer researchIn vitroEnzymeBiologyHuman breastGeneticsSynthesis and biological activityCancer therapeutics and mechanismsComputational Drug Discovery Methods