Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice
Shangfei Luo, Xiaoduo Zhao, Jintao Jiang, Bo Deng, Silin Liu, Honglin Xu, Qiaorui Tan, Yuan Chen, Ziyan Zhang, Xianmei Pan, Rentao Wan, Xiaoting Chen, Youfen Yao, Jing Li
Abstract
Macrophage Piezo1 deficiency limits the progression of liver fibrosis by inhibited inflammatory response and decreased secretion of CTSS. These findings suggest that targeting Piezo1 channel may be a potential strategy for treating hepatic fibrosis.
Topics & Concepts
FibrosisMacrophageInflammationSecretionPIEZO1LAMP1ChemistryCell biologyBiologyImmunologyIn vitroAutophagyMedicinePathologyApoptosisBiochemistryReceptorMechanosensitive channelsIon channelErythrocyte Function and PathophysiologyPhagocytosis and Immune RegulationLiver Disease Diagnosis and Treatment