Polymeric integration of structure-switching aptamers on transistors for histamine sensing
Bajramshahe Shkodra, Mattia Petrelli, Kyung-Ae Yang, Anna Tagliaferri, Paolo Lugli, Luisa Petti, Nako Nakatsuka
Abstract
histidine, the closest structural analog and precursor to histamine. Taken together, these results implied that target-specific aptamer conformational changes on CNTs facilitate signal transduction, which was corroborated by circular dichroism spectroscopy. Our work suggests that layer-by-layer polymer chemistry enables integration of structure-switching aptamers into flexible EG-CNTFETs for small-molecule biosensing.
Topics & Concepts
AptamerCovalent bondNanotechnologyHistamineMaterials scienceTransistorChemistryVoltageBiologyMolecular biologyPhysicsEndocrinologyQuantum mechanicsOrganic chemistryAdvanced biosensing and bioanalysis techniquesMolecular Junctions and NanostructuresNanopore and Nanochannel Transport Studies