Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFRL858R/T790M NSCLCs by the conformation constrained strategy
Yang Chen, Linlin Yang, Hui Qiao, Zhongyu Cheng, Jiahao Xie, Wenjuan Zhou, Xin Huang, Yaoxuan Jiang, Bin Yu, Wen Zhao
Topics & Concepts
T790MChemistryPyrimidineEpidermal growth factor receptorIC50EGFR inhibitorsMutantIn vitroTyrosine kinaseCell growthOsimertinibStereochemistryCancer researchReceptorErlotinibBiochemistryGefitinibBiologyGeneLung Cancer Treatments and MutationsQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms