Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis
Xueting Wang, Rui Li, Lingxin Feng, Jing Wang, Qi Qi, Wenjie Wei, Zhuang Yu
Abstract
. Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment.
Topics & Concepts
PI3K/AKT/mTOR pathwayCancer researchLung cancerDownregulation and upregulationBiologyProtein kinase BmicroRNAMetastasisOncogeneCircular RNAKinaseSignal transductionCancerMedicineCell biologyCell cycleInternal medicineGeneBiochemistryGeneticsCircular RNAs in diseasesMicroRNA in disease regulation