Rapid SERS Analysis: From Laboratory to Real Sample

Haoyu Guo, Shengfu Zhi, Zeyu Zhao, Tianchu Gao, Hao Ma, Si-Heng Luo, Wei Zhang, Ping Guo, Bin Ren, Zhong‐Qun Tian, Guokun Liu

2025ACS Applied Materials & Interfaces21 citationsDOI

Abstract

On the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS), numerous reviews highlighted SERS advancements from different aspects, such as the historical evolution, enhancement mechanisms, quantitative analysis, and medical applications. However, how to develop the rapid SERS analysis for real samples has rarely been summarized yet. This review highlights the following three pivotal steps in this direction: (1) establishing reliable and highly selectively sensitive SERS analysis in the laboratory; (2) developing rapid sample pretreatment; and (3) AI-enhanced qualitative and quantitative SERS analysis.

Topics & Concepts

NanotechnologySurface-enhanced Raman spectroscopyMaterials scienceQualitative analysisRaman spectroscopyQuantitative analysis (chemistry)Sample (material)Sample preparationAnalytical Chemistry (journal)Data scienceComputer scienceRaman scatteringChromatographyOpticsChemistryPhysicsQualitative researchSociologySocial scienceGold and Silver Nanoparticles Synthesis and ApplicationsSpectroscopy Techniques in Biomedical and Chemical ResearchLaser-induced spectroscopy and plasma