In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment
Kaiyue Zhang, Shang Chen, Huimin Sun, Lina Wang, Huifang Li, Jinglei Zhao, Chuyue Zhang, Nana Li, Zhikun Guo, Zhibo Han, Zhongchao Han, Guoguang Zheng, Xiangmei Chen, Zongjin Li
Abstract
cells contributed to nephric tubule regeneration which significantly ameliorated the renal function after AKI. In summary, intravital lineage tracing with two-photon microscopy through an embedded abdominal imaging window provides a practical strategy to investigate the beneficial functions and to clarify the mechanisms of regenerative therapies in AKI.
Topics & Concepts
Mesenchymal stem cellRegeneration (biology)Cell biologySOX9Stem cellPathologyBiologyChemistryMedicineBiochemistryGeneGene expressionExtracellular vesicles in diseaseAcute Kidney Injury ResearchRenal and related cancers