A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature
Marina Ramos‐Martín, Ramón Lecuna, Luciana Cicco, Paola Vitale, Vito Capriati, Nicolás Ríos‐Lombardía, Javier González‐Sabín, Alejandro Presa Soto, Joaquín García‐Álvarez
Abstract
formed ketones, run under air at room temperature, allows the straightforward and chemoselective synthesis of tertiary alcohols with broad substrate scope and excellent conversions (up to 96%).
Topics & Concepts
ReagentChemistryLaccaseAlcohol oxidationAqueous solutionOne-pot synthesisSubstrate (aquarium)Aqueous mediumCatalysisOrganometallic chemistryCombinatorial chemistryOrganic chemistryEnzymeOceanographyGeologyChemical synthesis and alkaloidsOxidative Organic Chemistry ReactionsCatalytic Cross-Coupling Reactions