Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
Abdallah E. Abdallah, Reda R. Mabrouk, Maged Mohammed Saleh Al Ward, Sally I. Eissa, Eslam B. Elkaeed, Ahmed B. M. Mehany, Mariam A. Abo-Saif, Ola A. El-Feky, Mohamed S. Alesawy, Mohamed Ayman El‐Zahabi
Abstract
of 253 and 381 nM against HER2 and FGFR, respectively.
Topics & Concepts
SorafenibChemistryApoptosisIC50QuinazolineDocking (animal)PharmacologyLead compoundCancer researchStereochemistryHepatocellular carcinomaIn vitroBiochemistryBiologyMedicineNursingQuinazolinone synthesis and applicationsAngiogenesis and VEGF in CancerHER2/EGFR in Cancer Research